Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50140102

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_71599 (CHEMBL689131)

25±n/a nM

Citation

Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem47:1259-71 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

37749.45

Organism:

Homo sapiens (Human)

Description:

P30968

Residue:

328

Sequence:

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50140102

n/a

Name

BDBM50140102

Synonyms:

3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL23729

Type

Small organic molecule

Emp. Form.

C29H28F3N3O3

Mol. Mass.

523.5461

SMILES

COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2ccccc2)c1=O |wU:26.28,(4.84,1.97,;3.5,1.18,;3.51,-.38,;4.84,-1.13,;4.87,-2.67,;3.55,-3.44,;2.23,-2.67,;2.2,-1.16,;1.09,-.05,;.9,-3.45,;.9,-5,;2.24,-5.76,;-.42,-5.76,;-.42,-7.3,;-1.74,-8.07,;-3.07,-7.3,;-4.17,-6.2,;-4.4,-8.07,;-4.39,-9.61,;-3.04,-10.36,;-1.74,-9.6,;-.65,-10.67,;-1.76,-5.01,;-3.08,-5.76,;-1.76,-3.48,;-3.08,-2.71,;-3.08,-1.16,;-1.74,-.36,;-4.43,-.38,;-4.43,1.18,;-5.9,1.69,;-6.2,3.22,;-7.67,3.73,;-8.84,2.7,;-8.55,1.17,;-7.07,.68,;-.44,-2.7,;-.44,-1.16,)|

Structure