Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50140110

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_71445 (CHEMBL685317)

43±n/a nM

Citation

Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem47:1259-71 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

37749.45

Organism:

Homo sapiens (Human)

Description:

P30968

Residue:

328

Sequence:

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50140110

n/a

Name

BDBM50140110

Synonyms:

(R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione | 1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(R)-2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione | CHEMBL23969

Type

Small organic molecule

Emp. Form.

C28H27F3N4O3

Mol. Mass.

524.5342

SMILES

COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C)NCc2ccccn2)c1=O |r,wU:26.28,(4.78,5.66,;3.45,4.89,;3.45,3.35,;4.79,2.58,;4.79,1.04,;3.45,.27,;2.12,1.05,;2.12,2.58,;.79,3.35,;.79,.29,;.79,-1.25,;2.12,-2.02,;-.54,-2.01,;-.54,-3.55,;.8,-4.32,;2.12,-3.56,;.78,-2.78,;3.45,-4.32,;3.46,-5.87,;2.12,-6.64,;.79,-5.87,;-.55,-6.63,;-1.87,-1.25,;-3.2,-2.02,;-1.87,.29,;-3.2,1.05,;-4.53,.28,;-4.53,-1.26,;-5.87,1.05,;-7.2,.27,;-8.54,1.04,;-9.86,.26,;-11.19,1.02,;-11.21,2.57,;-9.87,3.34,;-8.53,2.58,;-.54,1.07,;-.54,2.61,)|

Structure