Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50143225 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_37506 (CHEMBL648136) |
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Ki | 1.9±n/a nM |
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Citation | Primofiore, G; Da Settimo, F; Taliani, S; Simorini, F; Patrizi, MP; Novellino, E; Greco, G; Abignente, E; Costa, B; Chelli, B; Martini, C N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor. J Med Chem47:1852-5 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50143225 |
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n/a |
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Name | BDBM50143225 |
Synonyms: | CHEMBL300762 | N,N-Dibutyl-2-[5-chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-2-oxo-acetamide |
Type | Small organic molecule |
Emp. Form. | C24H26Cl2N2O2 |
Mol. Mass. | 445.381 |
SMILES | CCCCN(CCCC)C(=O)C(=O)c1c([nH]c2ccc(Cl)cc12)-c1ccc(Cl)cc1 |
Structure |
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