| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50408410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_84042 (CHEMBL691888) |
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| EC50 | >50000±n/a nM |
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| Citation |  Eldrup, AB; Allerson, CR; Bennett, CF; Bera, S; Bhat, B; Bhat, N; Bosserman, MR; Brooks, J; Burlein, C; Carroll, SS; Cook, PD; Getty, KL; MacCoss, M; McMasters, DR; Olsen, DB; Prakash, TP; Prhavc, M; Song, Q; Tomassini, JE; Xia, J Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem47:2283-95 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50408410 |
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| n/a |
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| Name | BDBM50408410 |
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| Synonyms: | CHEMBL480143 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15N5O4 |
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| Mol. Mass. | 281.2679 |
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| SMILES | C[C@@]1(O)[C@@H](CO)O[C@H]([C@@H]1O)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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