Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 12 |
---|
Ligand | BDBM50171009 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_303378 (CHEMBL877449) |
---|
Ki | 3.3±n/a nM |
---|
Citation | Mincione, F; Starnotti, M; Masini, E; Bacciottini, L; Scrivanti, C; Casini, A; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett15:3821-7 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 12 |
---|
Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
BDBM50171009 |
---|
n/a |
---|
Name | BDBM50171009 |
Synonyms: | (3R)-3-{2-[({2-[4-(aminosulfonyl)phenyl]ethyl}amino)carbonothioyl]hydrazino}-4-oxobutanamide | CHEMBL181422 |
Type | Small organic molecule |
Emp. Form. | C13H19N5O4S2 |
Mol. Mass. | 373.451 |
SMILES | NC(CC(N)=O)C(=O)NC(=S)NCCc1ccc(cc1)S(N)(=O)=O |
Structure |
|