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TargetCarbonic anhydrase 12
LigandBDBM50171010
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303378
Ki 12±n/a nM
Citation Mincione FStarnotti MMasini EBacciottini LScrivanti CCasini AVullo DScozzafava ASupuran CT Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett 15:3821-7 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase
Synonyms:CA-XII | Carbonate dehydratase XII | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50171010
n/a
NameBDBM50171010
Synonyms:CHEMBL362636 | N-[4-(aminosulfonyl)phenyl]-2-(pentafluorophenyl)triazane-1-carbothioamide
TypeSmall organic molecule
Emp. Form.C13H10F5N5O2S2
Mol. Mass.427.373
SMILESNN(NC(=S)Nc1ccc(cc1)S(N)(=O)=O)c1c(F)c(F)c(F)c(F)c1F
Structure
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