| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50146552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_305270 |
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| IC50 | 950±n/a nM |
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| Citation |  Kempson, J; Pitts, WJ; Barbosa, J; Guo, J; Omotoso, O; Watson, A; Stebbins, K; Starling, GC; Dodd, JH; Barrish, JC; Felix, R; Fischer, K Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships. Bioorg Med Chem Lett15:1829-33 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
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| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105691.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00408 |
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| Residue: | 941 |
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| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
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| BDBM50146552 |
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| n/a |
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| Name | BDBM50146552 |
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| Synonyms: | 2-[7-Ethyl-6-(4-sulfamoyl-benzylamino)-7H-purin-2-ylamino]-4-methyl-thiazole-5-carboxylic acid ethyl ester | CHEMBL100503 | ethyl 2-(7-ethyl-6-(4-sulfamoylbenzylamino)-7H-purin-2-ylamino)-4-methylthiazole-5-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N8O4S2 |
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| Mol. Mass. | 516.596 |
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| SMILES | CCOC(=O)c1sc(Nc2nc(NCc3ccc(cc3)S(N)(=O)=O)c3n(CC)cnc3n2)nc1C |
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| Structure | 
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