| Reaction Details |
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 | Report a problem with these data |
| Target | Polyprenyl synthetase family protein |
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| Ligand | BDBM50165340 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302625 (CHEMBL839917) |
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| Ki | 50±n/a nM |
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| Citation |  Sanders, JM; Song, Y; Chan, JM; Zhang, Y; Jennings, S; Kosztowski, T; Odeh, S; Flessner, R; Schwerdtfeger, C; Kotsikorou, E; Meints, GA; Gómez, AO; González-Pacanowska, D; Raker, AM; Wang, H; van Beek, ER; Papapoulos, SE; Morita, CT; Oldfield, E Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. J Med Chem48:2957-63 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyprenyl synthetase family protein |
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| Name: | Polyprenyl synthetase family protein |
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| Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41078.35 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_330072 |
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| Residue: | 362 |
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| Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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| BDBM50165340 |
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| n/a |
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| Name | BDBM50165340 |
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| Synonyms: | BPH-461 | CHEMBL193722 | hydrogen 2-(3-fluoropyridinium-1-yl)-1-hydroxy-1-phosphonoethylphosphonate |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10FNO7P2 |
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| Mol. Mass. | 301.1027 |
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| SMILES | OC(C[n+]1cccc(F)c1)(P(O)(O)=O)P(O)([O-])=O |
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| Structure | 
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