| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-8 |
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| Ligand | BDBM50171125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321471 (CHEMBL880412) |
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| IC50 | >10000±n/a nM |
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| Citation |  Oppong, KA; Ellis, CD; Laufersweiler, MC; O'Neil, SV; Wang, Y; Soper, DL; Baize, MW; Wos, JA; De, B; Bosch, GK; Fancher, AN; Lu, W; Suchanek, MK; Wang, RL; Demuth, TP Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis. Bioorg Med Chem Lett15:4291-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-8 |
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| Name: | Caspase-8 |
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| Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
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| Type: | Enzyme |
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| Mol. Mass.: | 55373.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14790 |
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| Residue: | 479 |
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| Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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| BDBM50171125 |
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| n/a |
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| Name | BDBM50171125 |
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| Synonyms: | CHEMBL371004 | Naphthalene-2-carboxylic acid {(S)-5-(3-fluoro-benzoyl)-1-[((S)-2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-2-oxo-[1,5]diazocan-3-yl}-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29FN4O7 |
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| Mol. Mass. | 576.5723 |
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| SMILES | OC1OC(=O)C[C@@H]1NC(=O)CN1CCCN(C[C@H](NC(=O)c2ccc3ccccc3c2)C1=O)C(=O)c1cccc(F)c1 |
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| Structure | 
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