| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Ligand | BDBM50173567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320930 (CHEMBL881474) |
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| Ki | >1000000±n/a nM |
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| Citation |  Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem48:5942-54 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Synonyms: | DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase |
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| Type: | Enzyme |
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| Mol. Mass.: | 26574.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33316 |
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| Residue: | 252 |
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| Sequence: | MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
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| BDBM50173567 |
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| n/a |
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| Name | BDBM50173567 |
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| Synonyms: | 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-fluoro-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione | CHEMBL195997 | dUTPase inhibitor, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25FN2O4Si |
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| Mol. Mass. | 344.4539 |
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| SMILES | CC(C)(C)[Si](C)(C)OCC1OC(CC1F)n1ccc(=O)[nH]c1=O |
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| Structure | 
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