Reaction Details |
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Target | H(+)-exporting diphosphatase |
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Ligand | BDBM50173796 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321446 (CHEMBL880254) |
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IC50 | 6500±n/a nM |
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Citation | Kotsikorou, E; Song, Y; Chan, JM; Faelens, S; Tovian, Z; Broderick, E; Bakalara, N; Docampo, R; Oldfield, E Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem48:6128-39 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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H(+)-exporting diphosphatase |
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Name: | H(+)-exporting diphosphatase |
Synonyms: | Vacuolar-type proton translocating pyrophosphatase 1 |
Type: | PROTEIN |
Mol. Mass.: | 85914.14 |
Organism: | Trypanosoma brucei |
Description: | ChEMBL_321446 |
Residue: | 826 |
Sequence: | MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPTAPGD
AVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEV
MRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVA
VEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDNDVLANGS
QSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFG
LGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGM
GSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVK
WAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGL
LIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHC
AGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTT
AAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKS
VGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTG
ILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAA
VIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
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BDBM50173796 |
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n/a |
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Name | BDBM50173796 |
Synonyms: | CHEMBL450938 | [(3-nitro-phenylamino)-phosphono-methyl]-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C7H10N2O8P2 |
Mol. Mass. | 312.1104 |
SMILES | OP(O)(=O)C(Nc1cccc(c1)[N+]([O-])=O)P(O)(O)=O |
Structure |
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