| Reaction Details |
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 | Report a problem with these data |
| Target | H(+)-exporting diphosphatase |
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| Ligand | BDBM50165966 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321446 (CHEMBL880254) |
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| IC50 | 4300±n/a nM |
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| Citation |  Kotsikorou, E; Song, Y; Chan, JM; Faelens, S; Tovian, Z; Broderick, E; Bakalara, N; Docampo, R; Oldfield, E Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem48:6128-39 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| H(+)-exporting diphosphatase |
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| Name: | H(+)-exporting diphosphatase |
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| Synonyms: | Vacuolar-type proton translocating pyrophosphatase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85914.14 |
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| Organism: | Trypanosoma brucei |
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| Description: | ChEMBL_321446 |
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| Residue: | 826 |
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| Sequence: | MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPTAPGD
AVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEV
MRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVA
VEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDNDVLANGS
QSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFG
LGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGM
GSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVK
WAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGL
LIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHC
AGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTT
AAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKS
VGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTG
ILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAA
VIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
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| BDBM50165966 |
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| n/a |
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| Name | BDBM50165966 |
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| Synonyms: | CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phosphono-methyl]-phosphonic acid | [(2,4-dichloro-phenyl)aminomethylene]-1,1-bisphosphonate |
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| Type | Small organic molecule |
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| Emp. Form. | C7H9Cl2NO6P2 |
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| Mol. Mass. | 336.003 |
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| SMILES | OP(O)(=O)C(Nc1ccc(Cl)cc1Cl)P(O)(O)=O |
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| Structure | 
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