| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50174710 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_325889 (CHEMBL863246) |
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| IC50 | 40±n/a nM |
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| Citation |  Revesz, L; Bollbuck, B; Buhl, T; Eder, J; Esser, R; Feifel, R; Heng, R; Hiestand, P; Jachez-Demange, B; Loetscher, P; Sparrer, H; Schlapbach, A; Waelchli, R Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett15:5160-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | CC-CKR-1 | CCR-1 | CCR1_MOUSE | CD_antigen=CD191 | Ccr1 | Cmkbr1 | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40904.59 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452291 |
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| Residue: | 355 |
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| Sequence: | MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLM
QHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTH
RTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRL
IFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPII
YVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
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| BDBM50174710 |
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| n/a |
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| Name | BDBM50174710 |
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| Synonyms: | CHEMBL200242 | N-(2-(3-(3-(4-fluorobenzyl)-3,8-diaza-bicyclo[3.2.1]octan-8-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)-2-(dimethylamino)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30ClFN4O2 |
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| Mol. Mass. | 484.993 |
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| SMILES | CN(C)CC(=O)Nc1cc(Cl)ccc1\C=C\C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 |
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| Structure | 
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