Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M3 | ||
| Ligand | BDBM50176730 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_327855 (CHEMBL863985) | ||
| Ki | 50±n/a nM | ||
| Citation |  Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett16:373-7 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M3 | |||
| Name: | Muscarinic acetylcholine receptor M3 | ||
| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 66151.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20309 | ||
| Residue: | 590 | ||
| Sequence: |
| ||
| BDBM50176730 | |||
| n/a | |||
| Name | BDBM50176730 | ||
| Synonyms: | (R)-3-(8-methoxyquinuclidin-8-yl)-1,1-di(pyridin-3-yl)prop-2-yn-1-ol | CHEMBL381469 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23N3O2 | ||
| Mol. Mass. | 349.4262 | ||
| SMILES | CO[C@@]1(CN2CCC1CC2)C#CC(O)(c1cccnc1)c1cccnc1 |wU:2.1,wD:2.11,THB:1:2:5.6:9.8,(24.67,-12.3,;26.2,-12.27,;27.01,-13.59,;27.57,-14.86,;28.86,-13.81,;30.34,-14.04,;29.7,-12.78,;28.24,-12.57,;27.86,-10.98,;28.59,-11.92,;25.67,-14.37,;24.35,-15.16,;23.03,-15.95,;22.24,-14.63,;21.7,-16.73,;21.72,-18.27,;20.41,-19.06,;19.06,-18.31,;19.04,-16.77,;20.36,-15.98,;23.81,-17.27,;23.07,-18.61,;23.85,-19.94,;25.38,-19.91,;26.13,-18.57,;25.35,-17.26,)| | ||
| Structure | 
| ||