| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain 2 |
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| Ligand | BDBM50183385 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_336664 (CHEMBL859281) |
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| IC50 | 4600±n/a nM |
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| Citation |  Desai, PV; Patny, A; Gut, J; Rosenthal, PJ; Tekwani, B; Srivastava, A; Avery, M Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem49:1576-84 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Falcipain 2 |
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| Name: | Falcipain 2 |
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| Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.60 |
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| Organism: | Plasmodium falciparum |
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| Description: | Recombinant falcipain-2. |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50183385 |
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| n/a |
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| Name | BDBM50183385 |
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| Synonyms: | CHEMBL203823 | N-(2-(furan-2-ylmethylthio)ethyl)-2-(4-hydroxy-6-propylpyrimidin-2-ylthio)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21N3O3S2 |
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| Mol. Mass. | 367.486 |
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| SMILES | CCCc1cc(=O)[nH]c(SCC(=O)NCCSCc2ccco2)n1 |
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| Structure | 
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