| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50179539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_340219 (CHEMBL865586) |
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| IC50 | 4.8±n/a nM |
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| Citation |  Shinozuka, T; Shimada, K; Matsui, S; Yamane, T; Ama, M; Fukuda, T; Taki, M; Naito, S 4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors. Bioorg Med Chem Lett16:1502-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50179539 |
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| n/a |
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| Name | BDBM50179539 |
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| Synonyms: | CHEMBL383551 | [4-((S)-2-{[1-(biphenyl-3-ylamino)-cyclohexanecarbonyl]-amino}-butylamino)-phenoxy]-acetic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C35H45N3O4 |
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| Mol. Mass. | 571.7495 |
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| SMILES | CC[C@@H](CNc1ccc(OCC(=O)OC(C)(C)C)cc1)NC(=O)C1(CCCCC1)Nc1cccc(c1)-c1ccccc1 |
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| Structure | 
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