| Reaction Details |
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 | Report a problem with these data |
| Target | Cystathionine beta-lyase MetC |
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| Ligand | BDBM50370856 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_425863 (CHEMBL856866) |
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| IC50 | 9000±n/a nM |
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| Citation |  Ejim, LJ; Blanchard, JE; Koteva, KP; Sumerfield, R; Elowe, NH; Chechetto, JD; Brown, ED; Junop, MS; Wright, GD Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. J Med Chem50:755-64 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cystathionine beta-lyase MetC |
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| Name: | Cystathionine beta-lyase MetC |
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| Synonyms: | Beta-cystathionase | CBL | Cysteine lyase | METC_ECOLI | metC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43211.38 |
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| Organism: | Escherichia coli K-12 |
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| Description: | ChEMBL_425863 |
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| Residue: | 395 |
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| Sequence: | MADKKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKHATRNRANGELFYGRRG
TLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYEPSQDFCSK
ILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAAVRSVVPDA
IIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLM
GQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALPGSKGHEFW
KRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRP
QGEIDFSGTLIRLHIGLEDVDDLIADLDAGFARIV
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| BDBM50370856 |
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| n/a |
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| Name | BDBM50370856 |
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| Synonyms: | CHEMBL376005 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H14N4O10S2 |
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| Mol. Mass. | 630.562 |
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| SMILES | [#8-]-[#7+](=O)-c1cc(cc2\[#6](=[#6](/C#N)C#N)-c3cc(cc(c3-c12)-[#7+](-[#8-])=O)S(=O)(=O)[#8]-c1ccccc1)S(=O)(=O)[#8]-c1ccccc1 |
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| Structure | 
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