Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50213577 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_436893 (CHEMBL905198) |
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Ki | 190±n/a nM |
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Citation | Chlon-Rzepa, G; Zmudzki, P; Zajdel, P; Bojarski, AJ; Duszynska, B; Nikiforuk, A; Tatarczynska, E; Pawlowski, M 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands. Bioorg Med Chem15:5239-50 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50213577 |
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n/a |
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Name | BDBM50213577 |
Synonyms: | 7-{3-[4-(3-chlorophenyl)-piperazin-1-yl]-propyl}-8-ethoxy-1,3-dimethyl-3,7-dihydropurine-2,6-dione | CHEMBL229123 |
Type | Small organic molecule |
Emp. Form. | C22H29ClN6O3 |
Mol. Mass. | 460.957 |
SMILES | CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCN1CCN(CC1)c1cccc(Cl)c1 |
Structure |
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