Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 7

Ligand

BDBM50213581

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_436895 (CHEMBL905200)

57±n/a nM

Citation

Chlon-Rzepa, G; Zmudzki, P; Zajdel, P; Bojarski, AJ; Duszynska, B; Nikiforuk, A; Tatarczynska, E; Pawlowski, M 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands. Bioorg Med Chem15:5239-50 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 7

Name:

5-hydroxytryptamine receptor 7

Synonyms:

5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

49852.62

Organism:

Rattus norvegicus (rat)

Description:

Rat cloned 5-HT7R.

Residue:

448

Sequence:

MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNSDHCGKKGHDT

BDBM50213581

n/a

Name

BDBM50213581

Synonyms:

7-[4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-butyl]-8-propoxy-1,3-dimethyl-3,7-dihydropurine-2,6-dione | CHEMBL390580

Type

Small organic molecule

Emp. Form.

C23H31N5O3

Mol. Mass.

425.5239

SMILES

CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCCN1CCc2ccccc2C1

Structure