Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM12935 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_441219 (CHEMBL891443) |
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Ki | 388±n/a nM |
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Citation | Wilkinson, BL; Bornaghi, LF; Houston, TA; Innocenti, A; Vullo, D; Supuran, CT; Poulsen, SA Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett17:987-92 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM12935 |
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n/a |
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Name | BDBM12935 |
Synonyms: | 4-({[4-(Aminosulfonyl)benzoyl]amino}methyl-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole | CHEMBL217683 | Glycoconjugate Benzene Sulfonamide 2ee | methyl (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(4-{[(4-sulfamoylphenyl)formamido]methyl}-1H-1,2,3-triazol-1-yl)oxane-2-carboxylate |
Type | Small organic molecule |
Emp. Form. | C17H21N5O9S |
Mol. Mass. | 471.442 |
SMILES | COC(=O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(CNC(=O)c2ccc(cc2)S(N)(=O)=O)nn1 |
Structure |
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