Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 12 |
---|
Ligand | BDBM12917 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_441219 (CHEMBL891443) |
---|
Ki | 8.3±n/a nM |
---|
Citation | Wilkinson, BL; Bornaghi, LF; Houston, TA; Innocenti, A; Vullo, D; Supuran, CT; Poulsen, SA Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett17:987-92 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 12 |
---|
Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
|
|
|
BDBM12917 |
---|
n/a |
---|
Name | BDBM12917 |
Synonyms: | CHEMBL217569 | O-propynyl ester derivative 3 | Prop-2-ynyl 4-sulfamoylbenzoate | prop-2-yn-1-yl 4-sulfamoylbenzoate |
Type | Small organic molecule |
Emp. Form. | C10H9NO4S |
Mol. Mass. | 239.248 |
SMILES | NS(=O)(=O)c1ccc(cc1)C(=O)OCC#C |
Structure |
|