| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
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| Ligand | BDBM50221073 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_449469 (CHEMBL899735) |
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| IC50 | >30000±n/a nM |
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| Citation |  Wright, SW; Ammirati, MJ; Andrews, KM; Brodeur, AM; Danley, DE; Doran, SD; Lillquist, JS; Liu, S; McClure, LD; McPherson, RK; Olson, TV; Orena, SJ; Parker, JC; Rocke, BN; Soeller, WC; Soglia, CB; Treadway, JL; Vanvolkenburg, MA; Zhao, Z; Cox, ED (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg Med Chem Lett17:5638-42 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase FAP |
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| Name: | Prolyl endopeptidase FAP |
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| Synonyms: | 170 kDa melanoma membrane-bound gelatinase | FAP | Fibroblast Activation Protein (FAP) | Fibroblast activation protein alpha | Integral membrane serine protease | SEPR_HUMAN | Seprase |
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| Type: | Enzyme |
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| Mol. Mass.: | 87712.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q12884 |
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| Residue: | 760 |
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| Sequence: | MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPN
WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYG
DEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVT
DERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYD
AISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPG
RRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGR
TDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQ
ITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVY
TERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD
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| BDBM50221073 |
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| n/a |
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| Name | BDBM50221073 |
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| Synonyms: | (3R,4S)-1-(6-(6-methoxypyridin-3-yl)pyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine | (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE | CHEMBL237786 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F3N5O |
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| Mol. Mass. | 401.385 |
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| SMILES | COc1ccc(cn1)-c1cc(ncn1)N1C[C@H](N)[C@H](C1)c1cc(F)c(F)cc1F |
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| Structure | 
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