| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Ligand | BDBM8726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450121 (CHEMBL900393) |
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| IC50 | 900±n/a nM |
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| Citation |  Ozawa, T; Kitagawa, H; Yamamoto, Y; Takahata, S; Iida, M; Osaki, Y; Yamada, K Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Bioorg Med Chem15:7325-36 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Synonyms: | Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI |
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| Type: | Enzyme |
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| Mol. Mass.: | 27861.12 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 262 |
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| Sequence: | MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIV
LQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDIS
SYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPE
GVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGI
SGEVVHVDGGFSIAAMNELELK
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| BDBM8726 |
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| n/a |
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| Name | BDBM8726 |
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| Synonyms: | 5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H7Cl3O2 |
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| Mol. Mass. | 289.542 |
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| SMILES | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
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| Structure | 
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