Reaction Details |
| Report a problem with these data |
Target | Glycogen synthase kinase-3 beta |
---|
Ligand | BDBM50207808 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_454902 (CHEMBL886931) |
---|
IC50 | 24±n/a nM |
---|
Citation | Zhang, HC; Boñaga, LV; Ye, H; Derian, CK; Damiano, BP; Maryanoff, BE Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett17:2863-8 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Glycogen synthase kinase-3 beta |
---|
Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
|
|
|
BDBM50207808 |
---|
n/a |
---|
Name | BDBM50207808 |
Synonyms: | 33-(pyrrolidin-1-yl)-6,16,26,32-tetraazaheptacyclo[29.2.2.1^{6,13}.1^{19,26}.0^{7,12}.0^{14,18}.0^{20,25}]heptatriaconta-1(33),7(12),8,10,13(37),14(18),19(36),20(25),21,23,31,34-dodecaene-15,17-dione | CHEMBL247271 |
Type | Small organic molecule |
Emp. Form. | C37H37N5O2 |
Mol. Mass. | 583.722 |
SMILES | O=C1NC(=O)C2=C1c1cn(CCCCc3ccc(CCCCn4cc2c2ccccc42)c(n3)N2CCCC2)c2ccccc12 |c:5| |
Structure |
|