| Reaction Details |
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 | Report a problem with these data |
| Target | Xaa-Pro dipeptidase |
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| Ligand | BDBM50232501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461055 (CHEMBL944087) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kim, D; Kowalchick, JE; Brockunier, LL; Parmee, ER; Eiermann, GJ; Fisher, MH; He, H; Leiting, B; Lyons, K; Scapin, G; Patel, SB; Petrov, A; Pryor, KD; Roy, RS; Wu, JK; Zhang, X; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem51:589-602 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Xaa-Pro dipeptidase |
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| Name: | Xaa-Pro dipeptidase |
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| Synonyms: | PEPD | PEPD_HUMAN | PRD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54541.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_159887 |
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| Residue: | 493 |
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| Sequence: | MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTD
TGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEK
YAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEI
VECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSS
YTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTA
DQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLG
AVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDH
LLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMA
GCDKAFTPFSGPK
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| BDBM50232501 |
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| n/a |
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| Name | BDBM50232501 |
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| Synonyms: | (2R)-4-[8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride | CHEMBL540888 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20F7N5O |
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| Mol. Mass. | 515.4266 |
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| SMILES | N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1Cc1ccccc1F)Cc1cc(F)c(F)cc1F |w:17.19| |
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| Structure | 
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