| Reaction Details |
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 | Report a problem with these data |
| Target | Xaa-Pro aminopeptidase 1 |
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| Ligand | BDBM50232504 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461054 (CHEMBL944086) |
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| IC50 | >10000±n/a nM |
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| Citation |  Kim, D; Kowalchick, JE; Brockunier, LL; Parmee, ER; Eiermann, GJ; Fisher, MH; He, H; Leiting, B; Lyons, K; Scapin, G; Patel, SB; Petrov, A; Pryor, KD; Roy, RS; Wu, JK; Zhang, X; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem51:589-602 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Xaa-Pro aminopeptidase 1 |
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| Name: | Xaa-Pro aminopeptidase 1 |
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| Synonyms: | Aminoacylproline aminopeptidase | Cytosolic aminopeptidase P | Soluble aminopeptidase P | X-Pro aminopeptidase 1 | X-prolyl aminopeptidase 1, soluble | XPNPEP1 | XPNPEPL | XPNPEPL1 | XPP1_HUMAN | sAmp |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69905.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_461054 |
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| Residue: | 623 |
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| Sequence: | MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA
GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD
PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD
KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD
RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE
TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI
SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY
KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG
LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV
LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL
QKQGRQEALEWLIRETQPISKQH
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| BDBM50232504 |
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| n/a |
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| Name | BDBM50232504 |
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| Synonyms: | (2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihydro[[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride | CHEMBL536089 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F6N5O |
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| Mol. Mass. | 435.3668 |
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| SMILES | CC1CN(C(C)c2nnc(n12)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |w:1.0,4.4| |
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| Structure | 
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