Reaction Details |
| Report a problem with these data |
Target | Xaa-Pro dipeptidase |
---|
Ligand | BDBM50232506 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_461055 (CHEMBL944087) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Kim, D; Kowalchick, JE; Brockunier, LL; Parmee, ER; Eiermann, GJ; Fisher, MH; He, H; Leiting, B; Lyons, K; Scapin, G; Patel, SB; Petrov, A; Pryor, KD; Roy, RS; Wu, JK; Zhang, X; Wyvratt, MJ; Zhang, BB; Zhu, L; Thornberry, NA; Weber, AE Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem51:589-602 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Xaa-Pro dipeptidase |
---|
Name: | Xaa-Pro dipeptidase |
Synonyms: | PEPD | PEPD_HUMAN | PRD |
Type: | PROTEIN |
Mol. Mass.: | 54541.05 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_159887 |
Residue: | 493 |
Sequence: | MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTD
TGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEK
YAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEI
VECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSS
YTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTA
DQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLG
AVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDH
LLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMA
GCDKAFTPFSGPK
|
|
|
BDBM50232506 |
---|
n/a |
---|
Name | BDBM50232506 |
Synonyms: | 2-[7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[[1,2,4]triazolo[4,3-a]pyrazin-8-yl](4-fluorophenyl)methanol hydrochloride | CHEMBL536536 |
Type | Small organic molecule |
Emp. Form. | C23H20F7N5O2 |
Mol. Mass. | 531.426 |
SMILES | N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1C(O)c1ccc(F)cc1)Cc1cc(F)c(F)cc1F |w:17.17,18.20| |
Structure |
|