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TargetBradykinin B1 receptor
LigandBDBM50371320
Substrate/Competitorn/a
Meas. Tech.ChEMBL_463209
Ki 0.43±n/a nM
Citation Wood MRSchirripa KMKim JJKuduk SDChang RKDi Marco CNDiPardo RMWan BLMurphy KLRansom RWChang RSHolahan MACook JJLemaire WMosser SDBednar RATang CPrueksaritanont TWallace AAMei QYu JBohn DLClayton FCAdarayn EDSitko GRLeonard YMFreidinger RMPettibone DJBock MG Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists. Bioorg Med Chem Lett 18:716-20 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:B1 BRADYKININ | B1 bradykinin receptor | B1R | BK-1 receptor
Type:Enzyme
Mol. Mass.:40508.87
Organism:Homo sapiens (Human)
Description:P46663
Residue:353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50371320
n/a
NameBDBM50371320
Synonyms:CHEMBL271283
TypeSmall organic molecule
Emp. Form.C19H16Cl2F4N6O2
Mol. Mass.507.269
SMILESC[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(cc1Cl)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Structure
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