| Reaction Details |
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 | Report a problem with these data |
| Target | NPC1-like intracellular cholesterol transporter 1 |
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| Ligand | BDBM50371518 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463744 (CHEMBL932102) |
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| Ki | >50000±n/a nM |
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| Citation |  Pfefferkorn, JA; Larsen, SD; Van Huis, C; Sorenson, R; Barton, T; Winters, T; Auerbach, B; Wu, C; Wolfram, TJ; Cai, H; Welch, K; Esmaiel, N; Davis, J; Bousley, R; Olsen, K; Mueller, SB; Mertz, T Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption. Bioorg Med Chem Lett18:546-53 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NPC1-like intracellular cholesterol transporter 1 |
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| Name: | NPC1-like intracellular cholesterol transporter 1 |
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| Synonyms: | NPCL1_RAT | Niemann-Pick C1-like protein 1 | Npc1l1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 146415.18 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_463744 |
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| Residue: | 1331 |
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| Sequence: | MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNT
PARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNF
VSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAA
ASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKI
APCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSA
VLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSF
IVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSY
KYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNT
SLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLAL
SCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEM
ESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRV
AVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLE
YQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAI
ILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFL
LHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPV
YFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDW
LTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDP
PNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITAD
LRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGI
LNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLE
RAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLP
VVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAA
RSSLPKSDQKF
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| BDBM50371518 |
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| n/a |
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| Name | BDBM50371518 |
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| Synonyms: | CHEMBL402308 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18F2N2O4 |
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| Mol. Mass. | 424.3968 |
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| SMILES | Oc1ccc(cc1)[C@@H]1[C@@H](CNC(=O)c2ccc(F)cc2)OC(=O)N1c1ccc(F)cc1 |
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| Structure | 
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