| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50069989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464567 (CHEMBL933253) |
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| IC50 | 1190±n/a nM |
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| Citation |  Dorsey, BD; Iqbal, M; Chatterjee, S; Menta, E; Bernardini, R; Bernareggi, A; Cassarà, PG; D'Arasmo, G; Ferretti, E; De Munari, S; Oliva, A; Pezzoni, G; Allievi, C; Strepponi, I; Ruggeri, B; Ator, MA; Williams, M; Mallamo, JP Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J Med Chem51:1068-72 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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| BDBM50069989 |
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| n/a |
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| Name | BDBM50069989 |
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| Synonyms: | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25BN4O4 |
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| Mol. Mass. | 384.237 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| |
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| Structure | 
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