| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50374852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_470053 (CHEMBL933431) |
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| IC50 | 460±n/a nM |
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| Citation |  Xie, YF; Sircar, I; Lake, K; Komandla, M; Ligsay, K; Li, J; Xu, K; Parise, J; Schneider, L; Huang, D; Liu, J; Sakurai, N; Barbosa, M; Jack, R Identification of novel series of human CCR1 antagonists. Bioorg Med Chem Lett18:2215-21 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50374852 |
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| n/a |
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| Name | BDBM50374852 |
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| Synonyms: | CHEMBL255797 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26BrClN2O3S |
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| Mol. Mass. | 513.875 |
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| SMILES | OC1(CCN(CC1)[C@H]1CCCN(C1)S(=O)(=O)c1ccccc1Br)c1ccc(Cl)cc1 |
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| Structure | 
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