| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C21 |
|---|
| Ligand | BDBM7460 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_470435 (CHEMBL936590) |
|---|
| Ki | 11000±n/a nM |
|---|
| Citation |  Dhagat, U; Endo, S; Hara, A; El-Kabbani, O Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors. Bioorg Med Chem16:3245-54 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member C21 |
|---|
| Name: | Aldo-keto reductase family 1 member C21 |
|---|
| Synonyms: | AK1CL_MOUSE | Akr1c21 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 36879.72 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_470435 |
|---|
| Residue: | 323 |
|---|
| Sequence: | MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDH
VGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPM
ALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKP
GLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPV
LGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN
RNMRYIPAAIFKGHPNWPFLDEY
|
|
|
|---|
| BDBM7460 |
|---|
| n/a |
|---|
| Name | BDBM7460 |
|---|
| Synonyms: | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one | 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate | CHEMBL50 | Quercetin | Quercetin (10) | Quercetin (21) | Quercetin (Qur) | US11021454, Compound Quercetin | US9180183, Quercetin | med.21724, Compound 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H10O7 |
|---|
| Mol. Mass. | 302.2357 |
|---|
| SMILES | Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
