| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase BTS1 |
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| Ligand | BDBM25266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_474166 (CHEMBL938424) |
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| Ki | 30±n/a nM |
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| Citation |  Guo, RT; Cao, R; Liang, PH; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AH Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A104:10022-7 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase BTS1 |
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| Name: | Geranylgeranyl pyrophosphate synthase BTS1 |
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| Synonyms: | BTS1 | GGPPS_YEAST | Geranylgeranyl diphosphate synthase (GGPPS) | Geranylgeranyl pyrophosphate synthase |
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| Type: | Protein |
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| Mol. Mass.: | 38647.44 |
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| Organism: | Saccharomyces cerevisiae (Yeast) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIV
SQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTK
EPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRL
MEALSPSSHHGHSLVPFINLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVH
ALNFTKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
NDNENKYLPDLASHSDTATNLHDELLYIIDHLSEL
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| BDBM25266 |
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| n/a |
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| Name | BDBM25266 |
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| Synonyms: | BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-phenylphenyl)phenyl]-1-phosphonoethyl}phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20O7P2 |
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| Mol. Mass. | 434.3161 |
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| SMILES | OC(Cc1cccc(c1)-c1ccc(cc1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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