| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50376414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_476356 (CHEMBL937482) |
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| IC50 | 3740±n/a nM |
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| Citation |  Zhang, D; Wang, L; Raghavan, N; Zhang, H; Li, W; Cheng, PT; Yao, M; Zhang, L; Zhu, M; Bonacorsi, S; Yeola, S; Mitroka, J; Hariharan, N; Hosagrahara, V; Chandrasena, G; Shyu, WC; Humphreys, WG Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling. Drug Metab Dispos35:150-67 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50376414 |
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| n/a |
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| Name | BDBM50376414 |
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| Synonyms: | CHEMBL254989 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N2O7 |
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| Mol. Mass. | 502.5152 |
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| SMILES | Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)C(=O)Oc2ccc(O)cc2)cc1)-c1ccccc1 |
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| Structure | 
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