Reaction Details |
| Report a problem with these data |
Target | Type-1 angiotensin II receptor A |
---|
Ligand | BDBM50376921 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_478822 (CHEMBL925709) |
---|
IC50 | 168±n/a nM |
---|
Citation | Cappelli, A; Nannicini, C; Gallelli, A; Giuliani, G; Valenti, S; Mohr, Gl; Anzini, M; Mennuni, L; Ferrari, F; Caselli, G; Giordani, A; Peris, W; Makovec, F; Giorgi, G; Vomero, S Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. J Med Chem51:2137-46 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Type-1 angiotensin II receptor A |
---|
Name: | Type-1 angiotensin II receptor A |
Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40910.53 |
Organism: | RAT |
Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
Residue: | 359 |
Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
|
|
|
BDBM50376921 |
---|
n/a |
---|
Name | BDBM50376921 |
Synonyms: | CHEMBL408227 |
Type | Small organic molecule |
Emp. Form. | C24H22ClN7O |
Mol. Mass. | 459.931 |
SMILES | CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(Cl)ccc2c1=O |
Structure |
|