| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin G |
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| Ligand | BDBM50052693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_508148 (CHEMBL1007397) |
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| IC50 | 1100±n/a nM |
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| Citation |  Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem282:20836-46 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin G |
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| Name: | Cathepsin G |
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| Synonyms: | CATG_HUMAN | CG | CTSG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28860.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469016 |
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| Residue: | 255 |
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| Sequence: | MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
TMRSFKLLDQMETPL
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| BDBM50052693 |
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| n/a |
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| Name | BDBM50052693 |
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| Synonyms: | (2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid ethyl ester | (2S,3S)-ethyl 3-(((S)-1-(isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylate | (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester | 3-[3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid ethyl ester | Aloxistatin | CHEMBL63440 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H30N2O5 |
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| Mol. Mass. | 342.4305 |
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| SMILES | CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C |r| |
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| Structure | 
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