Ki Summary

Reaction Details

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Target

Gamma-aminobutyric acid receptor subunit alpha-6

Ligand

BDBM50244261

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_491125 (CHEMBL991893)

58.6±n/a nM

Citation

Harris, D; Clayton, T; Cook, J; Sahbaie, P; Halliwell, RF; Furtmüller, R; Huck, S; Sieghart, W; DeLorey, TM Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. J Med Chem51:3788-803 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gamma-aminobutyric acid receptor subunit alpha-6

Name:

Gamma-aminobutyric acid receptor subunit alpha-6

Synonyms:

GABA A alpha6 | GABA receptor alpha-6 subunit | GABRA6 | GBRA6_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51029.60

Organism:

Homo sapiens (Human)

Description:

GABA A alpha6 0 HUMAN::Q16445

Residue:

453

Sequence:

MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI
VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY
SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE

BDBM50244261

n/a

Name

BDBM50244261

Synonyms:

5-Methyl-6-oxo-8-trimethylsilanylethynyl-3a,4,5,6-tetrahydro-1H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid tert-butyl ester | CHEMBL471977

Type

Small organic molecule

Emp. Form.

C22H29N3O3Si

Mol. Mass.

411.5695

SMILES

CN1CC2N(CN=C2C(=O)OC(C)(C)C)c2ccc(cc2C1=O)C#C[Si](C)(C)C |c:6|

Structure