| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Ligand | BDBM50017009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491118 (CHEMBL991886) |
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| Kd | 8.3±n/a nM |
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| Citation |  Harris, D; Clayton, T; Cook, J; Sahbaie, P; Halliwell, RF; Furtmüller, R; Huck, S; Sieghart, W; DeLorey, TM Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. J Med Chem51:3788-803 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| Synonyms: | Benzodiazepine central | GABA A Benzodiazepine brain | GABA A Benzodiazepine liver | GABA receptor alpha-1 subunit | GABA(A) receptor subunit alpha-1 | GABA-A | GABA-A receptor | GABRA1 | GBRA1_HUMAN | Gamma-aminobutyric acid receptor subunit alpha (GABAA) | TBPS | agonist GABA site |
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| Type: | Protein |
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| Mol. Mass.: | 51817.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14867 |
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| Residue: | 456 |
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| Sequence: | MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
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| BDBM50017009 |
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| n/a |
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| Name | BDBM50017009 |
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| Synonyms: | 2-Phenyl-2,3a-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one (CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS-8216) | 2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one | CGS 8216, 1 | CGS-8216 | CHEMBL19732 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11N3O |
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| Mol. Mass. | 261.278 |
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| SMILES | O=c1n([nH]c2c1cnc1ccccc21)-c1ccccc1 |
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| Structure | 
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