| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-1 |
|---|
| Ligand | BDBM50243982 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_491118 (CHEMBL991886) |
|---|
| Kd | 8±n/a nM |
|---|
| Citation |  Harris, D; Clayton, T; Cook, J; Sahbaie, P; Halliwell, RF; Furtmüller, R; Huck, S; Sieghart, W; DeLorey, TM Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit. J Med Chem51:3788-803 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gamma-aminobutyric acid receptor subunit alpha-1 |
|---|
| Name: | Gamma-aminobutyric acid receptor subunit alpha-1 |
|---|
| Synonyms: | Benzodiazepine central | GABA A Benzodiazepine brain | GABA A Benzodiazepine liver | GABA receptor alpha-1 subunit | GABA(A) receptor subunit alpha-1 | GABA-A | GABA-A receptor | GABRA1 | GBRA1_HUMAN | Gamma-aminobutyric acid receptor subunit alpha (GABAA) | TBPS | agonist GABA site |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51817.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14867 |
|---|
| Residue: | 456 |
|---|
| Sequence: | MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
|
|
|
|---|
| BDBM50243982 |
|---|
| n/a |
|---|
| Name | BDBM50243982 |
|---|
| Synonyms: | CHEMBL453324 | ethyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20N2O4 |
|---|
| Mol. Mass. | 328.3624 |
|---|
| SMILES | CCOC(=O)c1ncc2[nH]c3cc(OC)c(OC)cc3c2c1CC |
|---|
| Structure | 
|
|---|
Search and Browse
