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TargetSmall conductance calcium-activated potassium channel protein 2
LigandBDBM50264020
Substrate/Competitorn/a
Meas. Tech.ChEMBL_535790 (CHEMBL991555)
IC50 543±n/a nM
Citation Gentles, RG; Grant-Young, K; Hu, S; Huang, Y; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg Med Chem Lett18:5316-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Small conductance calcium-activated potassium channel protein 2
Name:Small conductance calcium-activated potassium channel protein 2
Synonyms:KCNN2 | KCNN2_HUMAN | SK2
Type:PROTEIN
Mol. Mass.:63788.70
Organism:Homo sapiens (Human)
Description:ChEMBL_480083
Residue:579
Sequence:
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVS
SSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYK
LGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTII
LLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTAR
LAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF
VMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIG
YGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK
NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLV
DLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFI
EAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50264020
n/a
NameBDBM50264020
Synonyms:CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)thiazol-2-yl)pyridin-2-amine | TCMDC-124275 | US9034574, I
TypeSmall organic molecule
Emp. Form.C13H10N4S
Mol. Mass.254.31
SMILESN(c1nc(cs1)-c1ccccn1)c1ccccn1
Structure
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