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TargetSmall conductance calcium-activated potassium channel protein 1
LigandBDBM50264020
Substrate/Competitorn/a
Meas. Tech.ChEMBL_535548 (CHEMBL986174)
IC50 43±n/a nM
Citation Gentles, RG; Grant-Young, K; Hu, S; Huang, Y; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg Med Chem Lett18:5316-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Small conductance calcium-activated potassium channel protein 1
Name:Small conductance calcium-activated potassium channel protein 1
Synonyms:KCNN1 | KCNN1_HUMAN | SK | Small conductance calcium-activated potassium channel protein 1 | Small conductance calcium-activated potassium channel protein 1 (KCa2.1)
Type:Protein
Mol. Mass.:60005.90
Organism:Homo sapiens (Human)
Description:Q92952
Residue:543
Sequence:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
DCG
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  Blast E-value cutoff:
BDBM50264020
n/a
NameBDBM50264020
Synonyms:CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)thiazol-2-yl)pyridin-2-amine | TCMDC-124275 | US9034574, I
TypeSmall organic molecule
Emp. Form.C13H10N4S
Mol. Mass.254.31
SMILESN(c1nc(cs1)-c1ccccn1)c1ccccn1
Structure
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