| Reaction Details |
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 | Report a problem with these data |
| Target | Small conductance calcium-activated potassium channel protein 3 |
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| Ligand | BDBM50264019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535544 (CHEMBL986170) |
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| IC50 | >30000±n/a nM |
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| Citation |  Gentles, RG; Grant-Young, K; Hu, S; Huang, Y; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg Med Chem Lett18:5316-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Small conductance calcium-activated potassium channel protein 3 |
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| Name: | Small conductance calcium-activated potassium channel protein 3 |
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| Synonyms: | K3 | KCNN3 | KCNN3_HUMAN | Small conductance calcium-activated potassium channel protein 3 | Small conductance calcium-activated potassium channel protein 3 (KCa2.3) |
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| Type: | Protein |
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| Mol. Mass.: | 82053.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UGI6 |
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| Residue: | 731 |
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| Sequence: | MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQ
PQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAIL
HPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKY
SGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNAT
HNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVI
ETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTY
ERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIAR
VMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRV
CERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVA
VVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKH
QRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLE
SKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTS
FPTPYTSSSSC
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| BDBM50264019 |
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| n/a |
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| Name | BDBM50264019 |
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| Synonyms: | 5-iodo-N-(4-(pyridin-2-yl)thiazol-2-yl)pyridin-2-amine | CHEMBL489282 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9IN4S |
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| Mol. Mass. | 380.207 |
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| SMILES | Ic1ccc(Nc2nc(cs2)-c2ccccn2)nc1 |
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| Structure | 
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