| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transporter |
|---|
| Ligand | BDBM50032379 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_493246 (CHEMBL948476) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Dyck, B; Tamiya, J; Jovic, F; Pick, RR; Bradbury, MJ; O'Brien, J; Wen, J; Johns, M; Madan, A; Fleck, BA; Foster, AC; Li, B; Zhang, M; Tran, JA; Vickers, T; Grey, J; Saunders, J; Chen, C Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain. J Med Chem51:7265-72 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transporter |
|---|
| Name: | Transporter |
|---|
| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69236.90 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Q63380 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
|
|
|
|---|
| BDBM50032379 |
|---|
| n/a |
|---|
| Name | BDBM50032379 |
|---|
| Synonyms: | (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide | (1S,2R)-2-Aminomethyl-1-phenyl-cyclopropanecarboxylic acid diethylamide | CHEMBL99946 | LEVOMILNACIPRAN |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H22N2O |
|---|
| Mol. Mass. | 246.348 |
|---|
| SMILES | CCN(CC)C(=O)[C@]1(C[C@H]1CN)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
