Ki Summary

Reaction Details

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Target

Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

Ligand

BDBM50241244

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_543345 (CHEMBL1023015)

IC50

46000±n/a nM

Citation

Freitas, RF; Prokopczyk, IM; Zottis, A; Oliva, G; Andricopulo, AD; Trevisan, MT; Vilegas, W; Silva, MG; Montanari, CA Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Bioorg Med Chem17:2476-82 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

Name:

Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

Synonyms:

G3PG_TRYCR

Type:

PROTEIN

Mol. Mass.:

39070.68

Organism:

Trypanosoma cruzi

Description:

ChEMBL_973242

Residue:

359

Sequence:

MPIKVGINGFGRIGRMVFQALCEDGLLGTEIDVVAVVDMNTDAEYFAYQMRYDTVHGKFK
YEVTTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTAKAAA
EGHLRGGARKVVISAPASGGAKTLVMGVNHHEYNPSEHHVVSNASCTTNCLAPIVHVLVK
EGFGVQTGLMTTIHSYTATQKTVDGVSVKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTQ
GKLTGMSFRVPTPDVSVVDLTFTAARDTSIQEIDAALKRASKTYMKGILGYTDEELVSAD
FINDNRSSIYDSKATLQNNLPKERRFFKIVSWYDNEWGYSHRVVDLVRHMASKDRSARL

BDBM50241244

n/a

Name

BDBM50241244

Synonyms:

(E)-((2R,3S,4S,5R,6S)-6-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yloxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)methyl 3-(4-hydroxyphenyl)acrylate | CHEMBL266564 | CHEMBL499705 | Tiliroside | kaempferol 3-O-(6'' ''-O-E-p-coumaroyl)-beta-D-glucopyranoside | kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside | trans-Tiliroside

Type

Small organic molecule

Emp. Form.

C30H26O13

Mol. Mass.

594.5196

SMILES

O[C@@H]1[C@@H](COC(=O)C=Cc2ccc(O)cc2)O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H]1O |r,w:7.6|

Structure