| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM2681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565356 (CHEMBL955982) |
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| IC50 | 150±n/a nM |
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| Citation |  Olla, S; Manetti, F; Crespan, E; Maga, G; Angelucci, A; Schenone, S; Bologna, M; Botta, M Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. Bioorg Med Chem Lett19:1512-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM2681 |
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| n/a |
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| Name | BDBM2681 |
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| Synonyms: | 3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | Bisindolyl deriv. 11 | CHEMBL268769 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N4O2 |
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| Mol. Mass. | 426.5102 |
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| SMILES | CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:9| |
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| Structure | 
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