| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM50267053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565356 (CHEMBL955982) |
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| Ki | 4500±n/a nM |
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| Citation |  Olla, S; Manetti, F; Crespan, E; Maga, G; Angelucci, A; Schenone, S; Bologna, M; Botta, M Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. Bioorg Med Chem Lett19:1512-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM50267053 |
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| n/a |
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| Name | BDBM50267053 |
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| Synonyms: | 1-(2-(1H-indol-3-yl)ethyl)-4-acetyl-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1H-pyrrol-2(5H)-one | BAS-8770949 | CHEMBL476025 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N2O5 |
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| Mol. Mass. | 406.4312 |
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| SMILES | COc1cc(ccc1O)C1C(C(C)=O)C(=O)C(=O)N1CCc1c[nH]c2ccccc12 |
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| Structure | 
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