| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM16509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_498767 (CHEMBL1021959) |
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| IC50 | 3090±n/a nM |
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| Citation |  Kang, DH; Jun, KY; Lee, JP; Pak, CS; Na, Y; Kwon, Y Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem52:3093-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM16509 |
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| n/a |
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| Name | BDBM16509 |
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| Synonyms: | (2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]formamido}pentanoyl]pyrrolidine-2-carboxylic acid | CA074 | CHEMBL490920 | N-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline | PrNH-tES-Ile-Pro-OH | epoxysuccinyl derivative CA074 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H29N3O6 |
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| Mol. Mass. | 383.4394 |
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| SMILES | [H][C@@]1(O[C@]1([H])C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(O)=O)C(=O)NCCC |r| |
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| Structure | 
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