| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pro-cathepsin H |
|---|
| Ligand | BDBM50250191 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_498768 (CHEMBL1021960) |
|---|
| IC50 | 32570±n/a nM |
|---|
| Citation |  Kang, DH; Jun, KY; Lee, JP; Pak, CS; Na, Y; Kwon, Y Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem52:3093-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pro-cathepsin H |
|---|
| Name: | Pro-cathepsin H |
|---|
| Synonyms: | CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37402.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1459870 |
|---|
| Residue: | 335 |
|---|
| Sequence: | MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
|
|
|
|---|
| BDBM50250191 |
|---|
| n/a |
|---|
| Name | BDBM50250191 |
|---|
| Synonyms: | 3-acetyl-6-chloro-2-(2,4-dichlorophenylamino)-8-nitroquinolin-4(1H)-one | CHEMBL491348 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H10Cl3N3O4 |
|---|
| Mol. Mass. | 426.638 |
|---|
| SMILES | CC(=O)c1c(Nc2ccc(Cl)cc2Cl)nc2c(cc(Cl)cc2c1O)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
