Ki Summary

Reaction Details

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Target

Bifunctional epoxide hydrolase 2

Ligand

BDBM50295539

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_580015 (CHEMBL1051703)

IC50

16±n/a nM

Citation

Shen, HC; Ding, FX; Wang, S; Deng, Q; Zhang, X; Chen, Y; Zhou, G; Xu, S; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Tsai, C; Stevenson, AS; Pai, LY; Alonso-Galicia, M; Chen, X; Soisson, SM; Roy, S; Zhang, B; Tata, JR; Berger, JP; Colletti, SL Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. J Med Chem52:5009-12 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Bifunctional epoxide hydrolase 2

Name:

Bifunctional epoxide hydrolase 2

Synonyms:

Ephx2 | Epoxide hydrolase 2 | HYES_RAT

Type:

PROTEIN

Mol. Mass.:

62337.15

Organism:

Rattus norvegicus

Description:

ChEMBL_1465995

Residue:

554

Sequence:

MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI

BDBM50295539

n/a

Name

BDBM50295539

Synonyms:

4-(benzo[d]oxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide | CHEMBL552402

Type

Small organic molecule

Emp. Form.

C22H23N3O2

Mol. Mass.

361.4369

SMILES

O=C(NC1CC1c1ccccc1)N1CCC(CC1)c1nc2ccccc2o1

Structure