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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 | ||
| Ligand | BDBM50296348 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_581983 (CHEMBL1058963) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Li, R; Pourpak, A; Morris, SW Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem52:4981-5004 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 | |||
| Name: | Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 | ||
| Synonyms: | Bcr-Abl | Bcr/Abl fusion protein | Breakpoint cluster region protein /Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1/Breakpoint cluster region protein | ||
| Type: | Enzyme | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Tyrosine-protein kinase ABL1 | ||
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122897.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00519 | ||
| Residue: | 1130 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Breakpoint cluster region protein | ||
| Synonyms: | BCR | BCR1 | BCR_HUMAN | Bcr/Abl fusion protein | Breakpoint cluster region protein | D22S11 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 142824.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_305348 | ||
| Residue: | 1271 | ||
| Sequence: |
| ||
| BDBM50296348 | |||
| n/a | |||
| Name | BDBM50296348 | ||
| Synonyms: | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | CHEMBL551064 | NVP-AEW541 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27N5O | ||
| Mol. Mass. | 425.5255 | ||
| SMILES | Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@@H](C1)N1CCC1 |r,wU:26.32,wD:24.27,(12.58,1.25,;12.59,-.29,;11.26,-1.07,;11.26,-2.61,;12.59,-3.38,;13.92,-2.61,;15.4,-3.09,;16.31,-1.83,;15.4,-.58,;15.87,.89,;14.85,2.02,;15.32,3.49,;16.83,3.81,;17.87,2.67,;19.37,2.99,;20.4,1.84,;21.91,2.16,;22.94,1.01,;24.44,1.33,;24.92,2.8,;23.88,3.95,;22.38,3.62,;17.39,1.2,;13.92,-1.06,;15.87,-4.56,;15.17,-5.92,;16.54,-6.63,;17.25,-5.26,;17.01,-8.1,;16.3,-9.45,;17.67,-10.16,;18.37,-8.79,)| | ||
| Structure | 
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